Dr Grace Liu

Dr. Grace Liu PharmD is a trained functional medicine practitioner and founder of The Gut Institute. She is a clinical pharmacist with a doctorate in practice for 19+ years and specializes in complex disease management. She consults and helps clients gain optimal performance through rebuilding the microbiome after damage from modern living.

Grace uses nutrigenomic tools and other advanced functional lab testing. Currently she is training some functional medicine leaders to approach gut protocols with her expertise. Clients include ancestral health movement leaders and a UFC MMA fighter in the top 10. She has been invited to speak at summits, podcasts, Ancestral Health Symposium (USA) (2016, 2014, 2011), interviewed for a microbiome documentary (by ‘Microbirth’ producers) and Women’s Health  magazine on the skin-gut microbiome.  Recently she shared the stage with Dr David Perlmutter (author Grain Brain) on the Expert Microbiome Panel at Paleof(x)16 in Austin, Texas.

PRESENTATION: Pharmaceutical Fecal Failures (SER-109, FMTs) and How To Rebuild the Best Hybrid Ancestral-Modern Gut Microbiome

In 2016 a pharmaceutical company completed Phase II trials for a spore probiotic to combat iatrogenic Clostridium difficile colitis infections (CDI). The trial unexpectedly failed. Placebo performed infinitely better than treatment arms. What changes in the gut microbiome failed to happen but appeared to widely occur in successful cures and treatments with fecal microbiota transplants (FMT)? FMTs are allowed under limited FDA approval in the USA but have almost no therapeutic benefit in disease states outside of C difficile infections.

I will discuss potential reasons why pharmaceuticals and FMTs have failed. Understanding of the behavior and physiology of human gut microbiome provides clues to how to rebuild the microbiome and reset its functionality such as degrading plant oxalates. Many individuals cannot tolerate oxalate rich foods (kale, green vegetables, seeds, nuts, legumes, tubers) yet after resurrecting the ancestral core microbiota, food intolerances such as oxalate rich foods can be recovered.


  • Describe the recent pharmaceutical drug (SER-109 Phase II) and FMT (fecal microbiota transplant) failures for Clostridium difficile infections (CDI) in 2016 and FMT failures for non-CDI conditions.
  • What microbiome changes occur when successful FMT and probiotic cures of CDI are achieved?
  • How has ubiquitous microbiome damage by antibiotics, sanitizers, C-sections, dearth of breastfeeding, sterilized food and crops and low prebiotic diets challenge immunity and health?
  • Please list the potential gut risk factors with the Paleo Diet, SCD, GAPS and Ketogenic Diet?
  • Discuss 5 strategies to rebuild the best hybrid ancestral-modern gut microbiome